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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP4K2
All Species:
7.88
Human Site:
S437
Identified Species:
15.76
UniProt:
Q12851
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12851
NP_004570.2
820
91556
S437
P
P
P
S
G
P
N
S
S
P
L
L
P
T
A
Chimpanzee
Pan troglodytes
XP_001166072
820
91534
S437
P
P
P
S
G
P
D
S
S
P
L
L
P
T
A
Rhesus Macaque
Macaca mulatta
A4K2T0
487
55587
M143
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
Dog
Lupus familis
XP_540880
866
95490
W491
P
P
L
L
P
T
A
W
A
T
M
K
H
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61161
821
91247
S438
A
P
P
A
G
P
G
S
P
A
L
L
P
T
A
Rat
Rattus norvegicus
Q924I2
873
98660
Q490
R
D
G
S
V
H
Q
Q
Q
S
E
Q
R
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515144
898
100018
E513
K
L
I
N
E
N
A
E
G
L
G
P
A
P
Q
Chicken
Gallus gallus
Q5ZJK4
486
55318
M142
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
Frog
Xenopus laevis
Q6PA14
485
55246
H141
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
Zebra Danio
Brachydanio rerio
Q7ZUQ3
492
56062
A148
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8T0S6
669
75091
G323
Q
R
A
N
R
S
F
G
G
V
L
A
A
S
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23356
1096
122486
N523
S
K
M
G
G
H
H
N
G
R
S
R
E
E
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
25.8
87.3
N.A.
93.7
53.3
N.A.
49.8
25.7
25.9
26.2
N.A.
25.3
N.A.
23.9
N.A.
Protein Similarity:
100
99.8
40.6
90.6
N.A.
95.6
70
N.A.
65.8
40
41
41.2
N.A.
43.4
N.A.
40.5
N.A.
P-Site Identity:
100
93.3
0
13.3
N.A.
66.6
6.6
N.A.
0
0
0
6.6
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
6.6
26.6
N.A.
73.3
6.6
N.A.
6.6
6.6
0
20
N.A.
20
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
9
0
0
17
9
9
9
0
9
17
0
25
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
9
0
9
0
0
0
0
0
0
17
0
% D
% Glu:
0
0
17
0
17
0
0
9
0
0
9
0
9
9
9
% E
% Phe:
0
0
0
0
0
0
25
0
9
0
0
0
0
0
0
% F
% Gly:
17
0
17
9
34
0
9
9
34
0
9
0
0
9
0
% G
% His:
0
0
9
0
0
34
9
9
0
0
0
17
9
9
0
% H
% Ile:
0
9
9
0
0
9
0
0
0
0
25
0
9
0
17
% I
% Lys:
17
17
0
0
0
0
9
0
0
17
0
17
0
9
0
% K
% Leu:
9
25
9
17
17
0
9
0
0
9
34
34
9
0
0
% L
% Met:
0
0
9
0
0
0
0
17
0
9
9
0
0
0
0
% M
% Asn:
0
0
0
17
0
9
9
9
0
9
0
0
0
9
0
% N
% Pro:
25
34
25
0
9
25
0
0
9
17
0
9
25
9
0
% P
% Gln:
9
0
0
0
0
0
9
9
9
0
0
9
0
0
17
% Q
% Arg:
9
9
0
9
9
0
0
0
17
9
9
9
25
0
9
% R
% Ser:
9
0
0
25
0
9
0
25
17
9
9
0
0
9
9
% S
% Thr:
0
0
0
0
0
9
0
0
0
9
0
0
0
25
17
% T
% Val:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
17
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _